84-2358-83　［取扱停止］LRP1 (A2MR, Alpha 2 macroglobulin Receptor, alpha 2MR, Alpha-2-macroglobulin Receptor, APOER, Apolipoprotein E Receptor, APR, CD 91, CD91, CD91 Antigen, Low density lipoProtein Receptor Related Protein 1, Low density lipoProtein Related Protein 1, Low-density lipoProtein Receptor-Related Protein 1 intracellular Domain, LRP 1, LRP 515, LRP 85, LRP, LRP ICD, LRP-1, ...　223943

特徴

• Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LRP1 (low density lipoprotein related protein), Megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, yWTD repeats and an O-linked sugar domain.
• LRP1, also designated LRP and alpha-2-Macroglobulin receptor, is an endocytic receptor that mediates the uptake of at least 15 ligands, including alpha-2-Macroglobulin and apoE.
• LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated.
• Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone.
• The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands.
• LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer’s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.