Epilepsy affects about 0.5% of the world’s population and has a large genetic component.
Epilepsy results from an electrical hyperexcitability in the central nervous system.
Potassium channels are important regulators of electrical signaling, determining the firing properties and responsiveness of a variety of neurons.
Benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, has been shown to be caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes.
KCNQ2 and KCNQ3 are voltage-gated potassium channel proteins with six putative transmembrane domains.
Both proteins display a broad distribution within the brain, with expression patterns that largely overlap.
Mutations of KCNQ4 affect the functions of sensory outer hair cells and lead to deafness.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of Kv7.4. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 650-695 of Human Kv7.4.
