84-2356-62　［取扱停止］KRAS (c Kirsten ras Protein, c-K-ras, c-Ki-ras, Cellular c Ki ras2 proto Oncogene, cK Ras, GTPase KRas, K RAS p21 Protein, K RAS2A, K RAS2B, K RAS4A, K RAS4B, K-Ras 2, KI RAS, Ki-Ras, Kirsten rat Sarcoma 2 Viral (v Ki ras2) Oncogene Homolog, KRAS, KRAS1, KRAS2, N-Terminally processed, NS, NS3, Oncogene KRAS2, PR310 cK ras Oncogene, RASK, RASK2, Transforming Protei ...　223829

特徴

• Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.Defects in KRAS are a cause of acute myelogenous leukemia (AML).
• AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.
• Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML).
• JMML is a pediatric myelodysplastic syndrome that constitutes ~30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia.
• It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.
• Defects in KRAS are the cause of Noonan syndrome type 3 (NS3).
• Defects in KRAS are a cause of gastric cancer (GASC).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.