84-2356-48　［取扱停止］KLRK1 (CD314, CD314 Antigen, D12S2489E, Killer Cell Lectin like Receptor Subfamily K Member 1, Killer Cell Lectin-like Receptor Subfamily K Member 1, KLR, Klrk1, NK Cell Receptor D, NK Lectin-like Receptor, NKG2 D Activating NK Receptor, NKG2 D Type II integral Membrane Protein, NKG2-D, NKG2-D Type II integral Membrane Protein, NKG2-D-Activating NK Receptor, Nkg2d ...　223822

特徴

• The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily.
• The KIR/LIR family includes p91A (also designated pp130 or PIR-B, for paired Immunoglobulin-like receptor-B) and p91B (also designated PIR-A).
• p91A acts as an inhibitory receptor through interactions with SHP-1, whereas p91B acts as an activating receptor.
• CD94, NKG2 and Ly-49 are members of the C-type lectin superfamily of type II membrane glycoproteins.
• CD94 forms heterodimers with NKG2 isoforms on the surface of NK cells, whereas Ly-49 isoforms form homodimers.
• NKG2-D, expressed on NK cells, yδ T cells, and CD8+ alphabeta T cells, is a receptor for the stress inducible protein MICA, an antigen frequently expressed in epithelial tumors.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.