The activity of natural killer (NK) cells is regulated by members of multiple receptor families that recognize class I MHC molecules, such as the killer cell inhibitory receptor/leukocyte immunoglobulin-like receptor (KIR/LIR) family and the C-type lectin superfamily (1,2).
The KIR/LIR family includes p91A (also designated pp130 or PIR-B, for paired Immuno-globulin-like receptor-B) and p91B (also designated PIR-A).
p91A acts as an inhibitory receptor through interactions with SHP-1, whereas p91B acts as an activating receptor (3-4).
CD94, NKG2 and Ly-49 are members of the C-type lectin superfamily of type II membrane glycoproteins (5-7).
CD94 forms heterodimers with NKG2 isoforms on the surface of NK cells, whereas Ly-49 isoforms form homodimers (5,6).
NKG2-D, expressed on NK cells, gdT cells, and CD8+ alphaß T cells, is a receptor for the stress inducible protein MICA, an antigen frequently expressed in epithelial tumors (8).
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of KLRD1. Species Crossreactivity: Human
