Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes.
Kallikrein-8 (KLK8), also called neuropsin precursor, ovasin or serine protease 19, is a 260 amino acid secreted protein involved in hippocampal plasticity.
Two isoforms exist for this protein.
Isoform 1 is the primary form of KLK8 found predominantly in the pancreas.
Isoform 2 contains an additional 46 amino acids after amino acid 23 and is predominantly expressed in adult brain and hippocampus.
Isoform 2 is not common to the mouse homolog or other primate homologs.
In humans, the T to A mutation (c.71-127T>A) leads to the splice variant seen in the human brain.
Both isoforms are detected in fetal brain and placenta.
In some cancer cells, KLK8 expression can suppress tumor cell invasiveness and lead to a favorable clinical outcome.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of Cleaved-KLK8. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 11-60 of Human KLK8.
