84-2356-32　［取扱停止］KLK11, Cleaved (Kallikrein-11, hK11, Hippostasin, Serine Protease 20, Trypsin-like Protease, Kallikrein-11 inactive Chain 1, Kallikrein-11 inactive Chain 2, KLK11, PRSS20, TLSP, UNQ649/PRO1279, Kallikrein 11, Kallikrein11) 100ul　223814

特徴

• Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes.
• Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors.
• The function of the other members of KLK gene family is currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis.
• The human KLK gene family consists of 15 serine proteases.
• The human KLK genes are clustered on chromosome 19q13.
• Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop.
• Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression .
• KLK2 is also known as glandular kallikrein 2, tissue kallikrein or HGK-1, and KLK3 is known as prostate-specific antigen (PSA).
• Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics.
• KLK4, KLK5, KLK9, KLK13, KLK12 and KLK14 have been previously known as KLK-L1, KLK-L2, KLK-L3, KLK-L4, KLK-L5 and KLK-L6, respectively.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.