Small-conductance, calcium-activated K+ channels (SK channels) are activated in a voltage-independent manner, and they have a small unit conductance and high sensitivity to calcium.
SK channels 1-3 contain intracellular N- and C- termini and 6 conserved transmembrane segments.
SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed.
SK channels influence most excitable cells and participate in afterhyperpolarization (AHP) and spike-frequency adaptation.
Human SK3 is a 731 amino acid protein that is expressed in muscles upon denervation, and it is a component of the presynaptic compartment in mature neuromuscular junctions.
SK3 may also play a regulatory role in synaptic transmission.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of KCNN3. Species Crossreactivity: Human, mouse, rat
