84-2355-42　［取扱停止］KAT6B (Histone Acetyltransferase KAT6B, Histone Acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2, TIP60 Protein 4, MYST-4, Monocytic Leukemia zinc Finger Protein-Related Factor, KAT6B, KIAA0383, MORF, MOZ2, MYST4) 50ul　223767

特徴

• MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription.
• The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins.
• These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation.
• Additional MOZ related proteins, including MORF (MOZ related factor) and Tip60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain.
• MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation.
• Tip60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.