Kidney amine oxidase (KAO), also called diamine oxidase (DAO) and amiloride-binding protein (ABP), is a member of the copper/topaquinone oxidase family.
Notable compounds degraded by KAO include putrescine, histamine, spermine and spermidine, as well as substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis.
The secreted KAO protein can be detected in the extracellular space of placenta and kidney.
Placental KAO is thought to play a role in the regulation of female reproductive function.
KAO consists of two isoforms due to alternative splicing.
Isoform 1 is the common 751 amino acid form while isoform 2 contains the additional 19 amino acids between residues 619 and 637.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size:100ul
Host:rabbit
Source Antibody:human
Grade:Affinity Purified
Purity:Purified by immunoaffinity chromatography.
Form:Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity:Recognizes endogenous levels of KAO. Species Crossreactivity: Human