Kallmann (KAL1) syndrome is an X-linked condition characterized by hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency, and a defective sense of smell, known as anosmia, due to the underdevelopment of the olfactory bulbs.
GnRH is a key regulator of reproduction and sexual behavior.
Anosmia associated with Kallmann syndrome is due to a defect in the migration and targeting of GnRH-secreting neurons and olfactory axons during embryonic development.
Mutations in the KAL1 gene are responsible for X-linked Kallmann syndrome.
The human KAL1 gene, located in the Xp22.3 region, encodes a 680 amino acid extracellular matrix adhesion protein, known as anosmin-1.
Anosmin-1 plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex.
Anosmin-1 can be detected in the basement membranes and/or interstitial matrices of various structures including bronchial tubes, muscular walls of the digestive tract and forebrain subregions.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of KAL1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 205-250 of Human KAL1.
