84-2355-21　［取扱停止］JNK3 (c Jun Kinase 3, c-Jun N-Terminal Kinase 3, cJun N Terminal Kinase 3, FLJ12099, FLJ33785, JNK3 alpha Protein Kinase, JNK3, JNK3A, MAP Kinase 10, MAP Kinase, MAP Kinase p49 3F12, MAPK 10, Mapk10, MGC50974, Mitogen Activated Protein Kinase 10, Mitogen-Activated Protein Kinase 10, MK10, p493F12, p54bSAPK, PRKM10, Protein Kinase Mitogen Activated 10, SAPK1b, Stre ...　223756

特徴

• MAPK10 (JNK3) is a member of the MAP kinase family.
• MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
• This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs).
• Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis.
• Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4).
• Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
• Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Applications:Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Immunofluorescence: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.