Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection.
Activated by TLR7 or TLR8 signaling.Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14) [MIM:612245].
IBD14 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
It is subdivided into Crohn disease and ulcerative colitis phenotypes.
Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon.
Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IRF-5. Species Crossreactivity: Human, mouse, rat
