84-2352-62　［取扱停止］ING4 (Brain my036 Protein, Candidate Tumor Suppressor p33 ING 1 Homolog, Candidate Tumor Suppressor p33 ING1 Homolog, D6Wsu147e, D6Xrf92, ING 1 like Protein, ING 4, ING1 like Protein, ING4, ING4_HUMAN, Inhibitor of Growth Family Member 4, Inhibitor of Growth Family Member 4 long Isoform, Inhibitor of Growth Protein 4, MGC12557, my036, p29 ING 4, p29 ING4, p29ING4) 100ul　223626

特徴

• Inhibitor of growth protein (ING) family of nuclear proteins, also designated ING tumor suppressor proteins, inhibit tumor progression by modulating the transcriptional outputs of signaling pathways, which in turn regulates cell proliferation.
• Members of this family include ING1, ING2, ING3, ING4 and INGX.
• ING4 localizes to the nucleus and may inhibit tumor progression by adjusting the transcriptional output of signaling pathways which regulate cell proliferation.
• When complexed with RELA, ING4 can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes.
• ING4 interacts with HIF prolyl hydroxylase 2 (EGLN1), which represses the activity of hypoxia inducible factor (HIF).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.