84-2352-35　［取扱停止］ILF3 (Interleukin Enhancer-Binding Factor 3, Double-stranded RNA-Binding Protein 76, DRBP76, M-phase Phosphoprotein 4, MPP4, Nuclear Factor Associated with dsRNA, NFAR, Nuclear Factor of Activated T-Cells 90kD, NF-AT-90, Translational Control Protein 80, TCP80, DRBF, MPHOSPH4, NF90) 50ul　223612

特徴

• NF90 (nuclear factor of activated T-cells 90 kDa), also known as NFAR, DRBF, DRBP76 (double-stranded RNA-binding protein 76), MPP4, MPHOSPH4 (M-phase phosphoprotein 4), ILF3 (interleukin enhancer binding factor 3) or TCP80 (translational control protein 80), is a ubiquitously expressed nuclear protein that exists in a heterodimer with NF45.
• NF90 contains two DRBM (double-stranded RNA(dsRNA-)-binding) domains and one DZF domain and, in association with NF45 primarily participates in the regulation of IL-2 expression by binding to the antigen receptor response element (ARRE) target sequence of the IL-2 enhancer.
• In neuronal cells, the NF45/NF90 heterodimer can repress human rhinovirus type 2 replication by binding to a 5' untranslated region of the viral RNA that encodes the internal ribosome entry site (IRES).
• NF45 and NF90 belong to the double-stranded RNA-binding protein family and both are substrates for the dsRNA-activated protein kinase, PKR.
• Due to alternative splicing events, six isoforms exist for NF90, namely NFAR-2 (or ILF3-E), NFAR-1 (or DRBP76), isoform 3, DRBP76alpha (or ILF3-A), DRBP76δ (also known as DRBP76γ or ILF3-C) and isoform 6.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.