84-2352-16　［取扱停止］IL31RA (Class I cytokine Receptor, CRL 3, CRL, CRL3, Cytokine Receptor like 3, Cytokine Receptor-like 3, GLM R, GLM-R, GLMR, Gp130 like monocyte Receptor, GP130 like Receptor, Gp130-like monocyte Receptor, Gp130-like Receptor, GPL, HGLM R, HGLM-R, HGLMR, IL 31 Receptor Subunit alpha, IL 31R Subunit alpha, IL 31RA, IL-31 Receptor Subunit alpha, IL-31R Subunit alpha ...　223602

特徴

• IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells.
• IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM).
• This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade.
• SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31.
• Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD).
• Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples.
• Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA.
• IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.