84-2352-03　［取扱停止］IL24 (C49A, FISP, IL 24, IL 4 induced secreted Protein, IL-24, IL10B, Il24, IL24_HUMAN, interleukin 24, Interleukin-24, MDA-7, MDA7, Melanocyte Associated Mda 7, Melanoma Differentiation association Protein 7, Melanoma Differentiation-Associated Gene 7 Protein, Mob5, ST16, Suppression of Tumorigenicity 16 (Melanoma Differentiation), Suppression of Tumorigenicity 1 ...　223596

特徴

• This gene encodes a member of the IL10 family of cytokines.
• It was identified as a gene induced during terminal differentiation in melanoma cells.
• The protein encoded by this gene can induce apoptosis selectively in various cancer cells.
• Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis.
• The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes.
• Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• [provided by RefSeq, Jul 2008]
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.