The orphan receptor ST2/T1 is a member of the IL-1R family, although it does not bind IL-1alpha, IL-1beta or IL-1R antagonist, and it is preferentially expressed on the surface of T helper cell type 2 (Th2) cells, but not Th1 cells.
The gene encoding human ST2 maps to chromosome 2q12.1 and its transcription is controlled by two distinct promoters, an upstream promoter, which directs transcription in hematopoietic cells, and a downstream promoter, which directs transcription in fibroblasts.
ST2 is also alternatively spliced to produce three variants: the secreted soluble form (ST2), which is expressed in fibroblasts; the membrane-bound form (ST2L), which is expressed in hematopoietic cells; and ST2V, which is localized on the plasma membrane and is expressed in the stomach, small intestine and colon.
ST2 has immunoregulatory properties and, therefore, may have therapeutic potential as an anti-inflammatory agent.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IL1RL1. Species Crossreactivity: Human
