84-2351-91　［取扱停止］IL1RAP (C3orf13, IL 1 Receptor accessory Protein, IL 1R 3, IL 1R3, IL 1RAcP, IL 1RAP, IL-1 Receptor accessory Protein, IL-1R-3, IL-1R3, IL-1RAcP, IL1 Receptor accessory Protein, IL1AP_HUMAN, IL1R3, IL1RAcP, Il1rap, Interleukin 1 Accessory Protein, interleukin 1 Receptor 3, Interleukin 1 Receptor accessory Protein, interleukin 1 Receptor accessory Protein beta, Int ...　223590

特徴

• Interleukin-1 (IL-1) is a key pro-inflammatory cytokine that has diverse actions in the brain as a regulator of host defense responses and a mediator of inflammation.
• Two major agonists, IL-1alpha and IL-1beta, bind to a single known functional type-1 IL-1 receptor (IL-1RI), which associates with the accessory protein (IL-1RAcP), resulting in signal transduction.
• IL-1F6, IL-1F8, and IL-1F9 signal through IL-1RAcP to activate NF˚B.
• The membrane bound form of IL-1RAcP (mIL-1RAcP) facilitates signal transduction.
• Two alternatively spliced isoforms, soluble IL-1RAcP (sIL-1RAcP) and sIL-1RAcP-beta, which lack transmembrane and intracellular domains, can inhibit IL-1 signaling.
• Although both mIL-1RAcP and sIL-1RAcP mRNAs are widely expressed in human tissue, their relative proportions differ significantly in a tissue-specific manner.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.