84-2351-87　［取扱停止］IL1R1 (Antigen CD121a, CD121 Antigen-like Family Member A, CD121A, CD121a Antigen, D2S1473, IL 1, IL 1R 1, IL 1R alpha, IL 1RT1, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, IL1 Inhibitor, IL1R, IL1R1, IL1R1_HUMAN, IL1RA, IL1RN, IL1RT1, Interleukin 1 Receptor alpha Type 1, Interleukin 1 Receptor antagonist Protein (IRAP), Interleukin 1 Receptor Type I, Interleukin Rec ...　223588

特徴

• Three structurally related ligands for IL-1Rs have been described.
• These include two agonists, IL-1alpha and IL-1beta, and a specific receptor antagonist, IL-1Ralpha.
• Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities.
• The IL-1Ralpha molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses.
• Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues.
• Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex.
• The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.