The proinflammatory cytokine Interleukin 17 (IL-17) is produced by activated T cells to elicit potent cellular responses.
IL-17 is secreted as a disulfide-linked homodimeric glycoprotein.
A human IL-17 homolog IL-17E is a ligand for EV127/IL-17BR, which is also known as IL-17 receptor homolog 1.
IL-17EmRNA is detected at very low levels in several peripheral tissues.
IL-17E induces the activation of NFκB and stimulates the production of the proinflammatory chemokine IL-8.
In addition, IL-17E has catabolic activity on human articular cartilage.
IL-17E is a unique pleiotropic cytokine that may be an important mediator of inflammatory and immune responses.
Another homolog of IL-17, IL-17F, is a secreted cytokine expressed only in activated CD4+ T cells and activated monocytes.
IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and regulates cartilage matrix turnover.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IL17F. Species Crossreactivity: Human
