Interleukin-13, or IL-13, is a pleiotropic cytokine that exhibits 30% sequence identity with IL-4 and shares many of the same biological activities.
Like IL-4, IL-13 affects monocytes, macrophages and B cells by upregulating the expression of CD23 and MHC proteins, and downregulating the expression of CD14.
Both IL-4 and IL-13 are secreted by activated T lymphocytes and are powerful regulators of inflammation.
Both inhibit the secretion of proinflammatory cytokines and chemokines from activated monocytes and stimulate the expression of IgE on activated B cells.
IL-13 contains five Cysteine residues and multiple N-linked glycosylation sites and has been reported to inhibit the production of IL-2 in natural killer cells.
IL-13 cDNA encodes a 131 amino acid precursor with a 20 amino acid signal peptide which is cleaved to generate a mature protein.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IL13. Species Crossreactivity: Human
