IL-22Ralpha2 (interleukin-22 receptor alpha-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22.
It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver.
IL-22Ralpha2 has a cytokine-binding domain that contains two FnIII domains.
Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower.
By binding to IL-22, IL-22Ralpha2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling.
This suggests that IL-22Ralpha2 may be important in regulating inflammatory responses.
In addition, IL-22Ralpha2 can be induced by lipopolysaccharide (LPS).
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IL-22Ralpha2. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human IL-22Rα2.
