The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells.
IL-11 also has the inhibiting effect of repressing adipogenesis in vitro.
The IL-11alpha receptor, IL-11Ralpha, is a member of the class 1 subgroup of the cytokine receptor family and exhibits structural similarity to the alpha subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor.
It is speculated that the IL-11Ralpha regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells.
Coexpression of gp130 and IL-11alpha is necessary for high-affinity binding of IL-11 to IL-11Ralpha.
It has also been found that coexpression of IL-11Ralpha and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of IL-11Ralpha. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to amino acids 330-380 of Human IL-11Rα.
