The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, one IFN-beta gene, one IFN-w (also known as IFN-alpha II1) gene, and a number of IFN-w pseudogenes, are clustered on human chromosome 9.
Interferons-alpha and -beta are cytokines that are widely known to induce potent antiviral activity.
IFN-alpha and -beta exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases.
IFN-w is antigenically different from human IFN-alpha, IFN-beta or IFN-y, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells.
The type I interferon receptor (IFN-alphaR) interacts with IFN-alpha, IFN-beta and IFN-w, and seems to be a multisubunit receptor.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of IFNB1. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human IFNB1.
