The genes encoding type I interferons(IFNs),which include 14 IFN-alpha genes (two of which are IFN-alpha1 and IFN-alpha13), one IFN-beta gene, one IFN-ω (also known asIFN-alphaII1) gene and a number of IFN-ωpseudogenes, are clustered on human chromosome 9.
IFN-alphaand -beta are cytokinesthat arewidelyknown to induce potent antiviral activity.
They exert a variety of other biological effects, including antitumor and immunomodulatory activities, and are increasingly used clinicallyto treat a range of malignancies, myelodysplasias and autoimmune diseases.
IFN-ω is antigenically different from human IFN-alpha, IFN-betaorIFN-y, butis a component of naturalmixtures ofIFNspecies produced byvirus-induced leukocytes or Burkitt’slymphoma cells.
The type I interferon receptor (IFN-alphaR) interactswith IFN-alpha, IFN-beta and IFN-ω, and seemsto be a multi-subunit receptor.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of IFN-alpha. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human IFN-α.
