84-2348-85　［取扱停止］HTATIP2 (30kD HIV 1 TAT interacting Protein, 30kD HIV-1 TAT-interacting Protein, 30kD HIV1 TAT interacting Protein, CC3, CC3, FLJ26963, HIV 1 Tat interacting Protein 2 30kDa, HIV 1 Tat interacting Protein 2, HIV-1 Tat interacting Protein 2 30kDa, HIV-1 Tat interacting Protein 2 30kDa, HIV-1 Tat interactive Protein 2 30kDa, HIV-1 Tat interactive Protein 2 30kDa, HI ...　223433

特徴

• TIP30 (30kDa HIV-1 TAT-interacting protein), also known as HTATIP2 (HIV-1 TAT-interactive protein 2) or CC3, is a ubiquitously expressed protein that functions as an oxidoreductase.
• It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induction of apoptosis.
• TIP30 interacts with the ERalpha-interacting coactivator NCoA-5 and functions to regulate liganded and unliganded ERalpha-mediated c-Myc transcription.
• More specifically, when overexpressed TIP30 represses c-Myc transcription mediated by ERalpha, while the deficiency of TIP30 leads to an increase in c-Myc transcription.
• In addition, TIP30 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II).
• Defects in TIP30 are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for TIP30 in antitumor therapy.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.