84-2348-83　［取扱停止］HSPB8 (Alpha Crystallin C Chain, Alpha-Crystallin C Chain, Charcot Marie Tooth Disease axonal Type 2L, Charcot Marie Tooth Disease spinal, CMT2L, CRYAC, DHMN 2, DHMN2, E2 induced Gene 1 Protein, E2-induced Gene 1 Protein, E2IG1, H11, Heat Shock 22kDa Protein 8, Heat Shock 27kDa Protein 8, Heat Shock Protein 22, Heat Shock Protein beta 8, Heat Shock Protein beta-8, ...　223431

特徴

• Crystallins are the major proteins expressed in the vertebrate eye lens, where they maintain the transparency and refractive index of the lens.
• Crystallins are divided into a, b and g families; b and g-crystallins compose a superfamily.
• Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions.
• a-crystallins consist of three gene products, aA, aB and aC-crystallin, which are members of the small heat shock protein family (HSP20).
• They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates.
• However, unlike other molecular chaperones, a-crystallins do not renature these proteins.
• Research indicates that binding occurs between membranes and aC-crystallin.
• The binding site appears to be at the polar-apolar interface in membrane protein (MIP26) and aC-crystallin; the lipid bilayer becomes less mobile with aC-crystallin binding.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.