17beta-HSD4 (17beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-beta Estradiol dehydrogenase type IV.
It belongs to the 17beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body.
17beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol ?-oxidation.
It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain.
17beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6.
17beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life.
They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of HSD17B4. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant full length Human HSD17B4.
Shelf Life：1year
Swiss Prot Number：P51659
EU Commodity Code：30021010
商品名：HSD17B4 (7b-HSD4, 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA Hydratase, 17 beta HSD 4, 17 beta HSD IV, 17 beta hydroxysteroid Dehydrogenase 4, 17-beta-HSD 4, 17-beta-hydroxysteroid Dehydrogenase 4, 17beta estradiol Dehydrogenase Type IV, 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24 enoyl CoA Hydratase, 3-alpha, 7-alpha, Beta hydroxyacyl Dehydrogenase, Beta keto Reductase, D 3 hydroxyacyl CoA deHydratase, D bifunctional Protein, D bifunctional Protein peroxisomal, D-bifunctional Protein, DBP, DHB4_HUMAN, EDH17B4, Enoyl-CoA Hydratase 2, Hsd17b4, MFE 2, MFE-2, MPF-2, Multifunctional Protein 2, Peroxisomal multifunctional Enzyme Type 2, Peroxisomal multifunctional Protein 2, SDR8C1, Short Chain Dehydrogenase/Reductase Family 8C Member 1,) 100ul
