17beta-HSD2 (17beta hydroxysteroid dehydrogenase type 2) belongs to the 17beta-HSD family of proteins that regulate the availability of steroids within a tissue.
17beta-HSD2 converts active steroids to their inactive form through its oxidative activity.
It is a key player in the inactivation of Estradiol and testosterone.
Due to the affects that 17beta-HSD2 has on the availability of estrogen, it has been extensively investigated for playing a possible role in breast tumor development, colon cancer development and the pathophysiology of endometriosis.
17beta-HSD2 is predominantly expressed in the placenta, endometrium and prostate but can also be found in the liver, small intestine, and kidney.
17beta-HSD2 is a membrane bound protein.
Tibolone, a treatment used for climacteric symptoms in menopausal women, functions in part by activating 17beta-HSD2.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of HSD17B2. Species Crossreactivity: Human
