84-2346-76　［取扱停止］HMGN2 (High Mobility Group (Nonhistone Chromosomal) Protein 17, High Mobility Group nucleosomal Binding Domain 2, High Mobility Group nucleosome-Binding Domain-Containing Protein 2, High Mobility Group Protein N2, HMG17, HMGN2, HMGN2_HUMAN, MGC5629, Non histone Chromosomal Protein HMG 17, Non-histone Chromosomal Protein HMG-17, Nonhistone Chromosomal Protein HMG 1 ...　223323

特徴

• The high-mobility group (HMG) proteins 14 and 17 are abundant chromosomal proteins that bind to nucleosomes and enhance transcription.
• HMG-14 and HMG-17 also function as architectural elements, which alter the structure of the chromatin fiber and enhance transcription from chromatin templates.
• HMG-14/17 proteins modify the nucleosomal organization of the 30 nm chromatin fiber and mediate the unfolding of the higher order chromatin structure thereby facilitating access to the underlying DNA sequence.
• Clustering of architectural elements, such as HMG proteins and linker histone subtypes into distinct domains, may lead to structural and functional heterogeneity along the chromatin fiber.
• In addition, HMG-14 and HMG-17 have been identified as constitutive components of mouse oocyte and embryonic chromatin that establish a link between the structure of embryonic chromatin and the normal progression of embryonic development .
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.