84-2346-65　［取扱停止］HMGB2 (High Mobility Group (Nonhistone Chromosomal) Protein 2, High Mobility Group box 2, High Mobility Group Protein 2, High Mobility Group Protein B2, high-mobility group (Nonhistone Chromosomal) Protein 2, HMG 2, HMG B2, HMG-B2, HMG-2, HMG2, HMGB-2) 50ul　223318

特徴

• High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin.
• Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix.
• HMG proteins synergize with Oct-2, members of the N κB family, ATF-2 and c-Jun to activate transcription.
• Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein.
• Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes.
• HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.