84-2344-87　［取扱停止］HIF-3alpha (Hypoxia-inducible Factor 3-alpha, HIF-3-alpha, HIF3-alpha, Basic-helix-loop-helix-PAS Protein MOP7, Class E basic Helix-Loop-Helix Protein 17, bHLHe17, HIF3-alpha-1, Inhibitory PAS Domain Protein, IPAS, Member of PAS Protein 7, PAS Domain-Containing Protein 7, BHLHE17, MOP7, PASD7, HIF3A) 50ul　223221

特徴

• Cell growth and viability is compromised by oxygen deprivation (hypoxia).
• Hypoxia-inducible factors, including HIF-1alpha, HIF-1beta (also designated Arnt 1), EPAS-1 (also designated HIF-2alpha) and HIF-3alpha, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis.
• Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family.
• In response to hypoxia, HIF-1alpha is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex.
• The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.