84-2344-79　［取扱停止］HIC2 (Hypermethylated in Cancer 2 Protein, Hic-2, HIC1-Related Gene on Chromosome 22 Protein Hic-3, Zinc Finger and BTB Domain-Containing Protein 30, HIC2, HRG22, KIAA1020, ZBTB30) 50ul　223217

特徴

• HIC-2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors.
• HIC-2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing.
• HIC-2 is highly expressed in cerebellum and is localized to the nucleus in cells.
• HIC-2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor.
• The gene sequence associated with HIC-2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HIC-2 could possess tumor suppressor capabilities.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.