84-2344-53　［取扱停止］HELLS (Helicase Lymphoid specific, Hells, HELLS_HUMAN, LSH, Lymphoid specific Helicase, Lymphoid-specific Helicase, Nbla10143, PASG, Proliferation Associated SNF2 like Protein, Proliferation-Associated SNF2-like Protein, SWI/SNF2 Related Matrix Associated Actin Dependent Regulator of chromatin Subfamily A Member 6, SWI/SNF2-Related Matrix-Associated Actin-Dependen ...　223203

特徴

• The SNF2 family of helicases are thought to act as transcriptional regulators by their ability to alter the structure of chromatin.
• One such member, Lymphoid-Specific Helicase (Lsh, also designated Hells for lymphoid-specific DNA helicase), is highly expressed in lymphoid precursor cells in adult animals and is required for the proliferation of peripheral T lymphocytes.
• Lsh is also expressed in fetal liver and more abundantly in fetal thymus.
• Lsh protein shows substantial homology to other members of the SNF2 family that are involved in chromatin remodeling and transcription, however does not show similarity to members involved in DNA repair or recombination.
• The similarity of Lsh to another SNF2 homolog, Mi-2, which functions as a transcriptional silencer in chromatin remodeling, suggests that Lsh may participate in chromatin repression to regulate transcription, rather than chromatin “opening”.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.