HDAC6 is a member of the class II mammalian histone deacetylases.
Human HDAC6 is composed of 1215 amino acid residues.
It possesses two separate putative catalytic domains.
Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein.
A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus.
The shuttling process may be a critical regulatory mechanism of HDAC6 function.
The expression of HDAC6 is tightly linked to the state of cell differentiation.
HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of HDAC6. Species Crossreactivity: Human, mouse, rat
