Histone deacetylases (HDACs) play an important role in the modification of chromatin structure and thus in the suppression and activation of transcription and cellular differentiation.
There are 11 members in the HDAC family that are classified into four classes.
Class I HDACs represent homologs of the yeast histone deacetylase RPD3, class II HDACs share strong homology with the yeast histone deacetylase HDA1, class III HDAC are closely related to the yeast SIR2 protein, and class IV HDACs comprises Histone deacetylase 11 (HDAC11)-related enzymes.
HDAC11 contains 347 amino acid residues.
HDAC11 contains conserved residues in the catalytic core regions shared by both class I and II mammalian HDAC enzymes.
Expression of HDAC11 is high in the kidney, heart, brain, skeletal muscle, and testis, and it localizes to the cell nucleus.
The human gene encoding for HDAC11 maps to chromosome 3p25.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of HDAC11. Species Crossreactivity: Human, mouse, rat
