Heparin cofactor II (HCII) is a glycoprotein in human plasma which rapidly inactivates Thrombin in the presence of dermatan sulfate.
Inhibition occurs by formation of a stable equimolar complex between HCII and Thrombin.
Certain clinical conditions, such as hepatic failure, disseminated intravascular coagulation, thalasemina and sickle cell anemia, display reduced levels of HCII.
However, during pregnancy, physiological levels of HCII expression are elevated.
HCII may regulate coagulation and may participate in processes such as inflammation, atherosclerosis and wound repair.
HCII is widely distributed among vertebrates and may have a common function in birds, amphibians and mammals.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of HC-II. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to amino acids 41-90 of Human HC-II.
