84-2343-55　［取扱停止］HAX1 (HAX 1, HAX-1, HAX1, HAX1_HUMAN, Hax1a, HCLS1 and PKD2 Associated Protein, HCLS1 Associated Protein, HCLS1 Associated Protein X 1, HCLS1-Associated Protein X-1, HCLSBP1, HS 1 Associated Protein X 1, HS 1 Binding Protein, HS1 associating Protein X 1, HS1 Binding Protein 1, HS1 Binding Protein, HS1-associating Protein X-1, HS1-Binding Protein 1, HS1BP1, HSP1BP- ...　223152

特徴

• The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases.
• It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin.
• It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body.
• Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.
• Two transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.