Gastrin, which is normally formed by mucosal cells in the gastric antrum and by the D cells of the pancreatic islets, is a hormone whose main function is to stimulate secretion of HCl by the gastric mucosa.
HCl, in turn, inhibits gastrin formation.
Gastrin also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Gastrin is regulated by epidermal growth factor in both mice and humans.
Gastrin is excreted in excess by pancreatic tumors in the Zollinger-Ellison syndrome.
Gastrin maps to human chromosome 17q12.
Gastrin-releasing peptide (GRP) stimulates the release of gastrin as well as other gastrointestinal hormones, in addition to acting as an autocrine growth factor for certain cell types.
GRP is known to promote lung tumorigenesis in model systems and, interestingly, is induced by retinoic acid.
GRP is involved in several functions with the hypothalamus, and is thought to play a role in regulating pituitary hormone secretion.
GRP maps to human chromosome 18q21.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of GRP. Species Crossreactivity: Human
