The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids.
The most abundant isoform is GR alpha.
GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation.
A significant class of genes suppressed by GR is controlled by the transcription factor AP-1.
GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids.
It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive.
More importantly, mutant GRs lacking the signaling domain remain constitutively active.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, pH 7.2, .02% sodium azide, 50% glycerol
Specificity：Recognizes endogenous levels of human GR. Species Crossreactivity: mouse
