G protein-coupled receptors(GPRs or GPCRs), also known asseven transmembrane receptors, heptahelical receptors or 7TMreceptors, aremembers of the largest protein family and play a role in many differentstimulus-response pathways.
G protein-coupled receptors mediate extracellularsignals into intracellularsignals(G protein activation).
Theyrespond to awide variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides.
GPR proteins are usuallyintegralseven passmembrane proteins with some conserved amino acid regions.
GPR112 (G protein-coupled receptor 112) is a 3,080 amino acid multi-pass membrane protein that belongsto the G-protein coupled receptor 2 family and LN-TM7 subfamily.
Localizing to cell membrane, GPR112 is highly expressed in normal enterochromaffin cells, aswell as neuroendocrine and primarylivercarcinoma.
GPR112 contains one GPS domain andmayfunction as an orphan receptor.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of GPR112. Species Crossreactivity: Human, mouse, rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：A synthetic peptide corresponding to residues in Human GPR112.
