84-2340-85　［取扱停止］gp91-phox/CYBB (Cytochrome b-245 Heavy Chain, CGD91-phox, Cytochrome b(558) Subunit beta, Cytochrome b558 Subunit beta, Heme-Binding Membrane Glycoprotein, gp91phox, NADPH Oxidase 2, Neutrophil cytochrome b 91kD Polypeptide, Superoxide-Generating NADPH Oxidase Heavy Chain Subunit, gp91-1, gp91-phox, p22 phagocyte B-cytochrome, CYBB, NOX2) 50ul　223011

特徴

• Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase.
• The superoxide-generating NADPH oxidase complex expresses in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells.
• It includes a membranebound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox.
• The p22- and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions.
• Mox1 and gp91 contain identical C-terminal sequence identity, yet possess distinct expression patterns.
• gp91-phox expresses in eosinophils, neutrophils, monocytes, and B-lymphocytes, whereas Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.