84-2340-59　［取扱停止］GNL3 (Guanine Nucleotide-Binding Protein-like 3, E2-induced Gene 3 Protein, Novel Nucleolar Protein 47, NNP47, Nucleolar GTP-Binding Protein 3, Nucleostemin, GNL3, E2IG3, NS) 50ul　222998

特徴

• Nucleostemin, also designated Nucleolar GTP-binding protein 3, is a member of the MMR1/HSR1 GTP-binding protein family.
• It is expressed in the nucleoli of adult CNS stem cells, primitive bone marrow cells, embryonic stem cells and in several cancer cell lines.
• Nucleostemin is often used as a stem cell marker.
• Overexpression or depletion of the protein can reduce cell proliferation in CNS stem cells.
• Nucleostemin shuttles between the nucleus and the nucleolus and may be important in maintaining the proliferative capacity of stem cells.
• Nucleostemin is important in the growth regulation of liver cancer, gastric cancer and several other cancer types.
• The gene encoding Nucleostemin is localized to chromosome 3p21.1.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.