84-2340-52　［取扱停止］GNB2L1 (G Protein beta 2 Subunit, G Protein Subunit beta 2, G Protein Subunit beta-2, GBB2_HUMAN, Gnb2, Gnb2l1, Guanine Nucleotide Binding Protein beta 2 Subunit, Guanine Nucleotide Binding Protein G I G S G T beta 2 Subunit 2, Guanine Nucleotide Binding Protein G Protein beta Polypeptide 2, Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit beta-2, OTTHUMP ...　222994

特徴

• Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function.
• Receptor for activated C kinases, termed RACKs, are intracellular receptors for activated PKC that may be involved in the activation-induced translocation of PKC.
• RACK1 (receptor for activated C kinase 1) is a 317 amino acid G protein b subunit-like protein that functions as a RACK and inhibits the activity of Src tyrosine kinases.
• In response to PKC activation, the intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII colocalize to the same sites.
• RACK1 is therefore thought to be a shuttling protein for PKC bII.
• A deficit in RACK1 may be associated with impaired PKC activation in the aging brain.
• The RACK1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome 5q35.3.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.