84-2339-18　［取扱停止］GEMIN2 (Gem-Associated Protein 2, Gemin-2, Component of gems 2, Survival of motor neuron Protein-interacting Protein 1, SMN-interacting Protein 1, GEMIN 2, SIP1) 100ul　222924

特徴

• Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord.
• SMA is caused by deletion or loss-of-function mutations in the SMN (survival of motor neuron) gene.
• Gemin2 (formerly known as SIP1 for SMN interacting protein) associates directly with SMN and is a part of the SMN complex containing Gemin3 (a DEAD-box RNA helicase), Gemin4, Gemin5 and Gemin6, as well as several spliceosomal snRNP proteins.
• The SMN complex plays an essential role in splicesomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus.
• It is found in both the cytoplasm and the nucleus.
• The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies).
• The SMN-Gemin2 complex is associated with spliceosomal snRNAs U1 and U5.
• Gemin2 is expressed in spinal cord.
• It can be induced by TGFbeta treatment and expression is high in several E-cadherin negative human carcinoma cell lines.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.