84-2339-03　［取扱停止］GDF5 (BMP14, Cartilage derived morphogenetic Protein 1, Cartilage-derived morphogenetic Protein 1, CDMP-1, CDMP1, GDF-5, Gdf5, GDF5_HUMAN, Growth Differentiation Factor 5, Growth/Differentiation Factor 5, LAP4, OS5, Radotermin, SYNS2) 50ul　222917

特徴

• Growth/differentiation factors (GDFs) are members of the TGF superfamily.
• Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis.
• GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development.
• Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members.
• GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary.
• GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis.
• It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation.
• GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs.
• GDF-6 and GDF-7 are closely related to GDF-5.
• GDF-8 has been shown to be a negative regulator of skeletal muscle mass.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.