GBDR1 (glialblastoma cell differentiation-related protein 1), also known as UBAC1 (ubiquitin-associated domain-containing protein 1), KPC2 or UBADC1, is a 405 amino acid protein that localizes to the cytoplasm and contains one ubiquitin-like domain, one STI1 domain and two UBA domains.
Expressed ubiquitously with highest expression in heart and skeletal muscle, GBDR1 functions as a non-catalytic subunit of the KPC E3 ubiquitin-protein ligase complex, of which RNF123 is the catalytic subunit.
Existing as a critical component of the KPC complex, GBDR1 is essential for the ubiquitination and proteasome-mediated degradation of p27 during the G1 phase of the cell cycle.
The gene encoding GBDR1 maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:1000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.05% sodium azide, pH 7.2.
Specificity：Recognizes endogenous levels of GBDR1. Species Crossreactivity: Human
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to amino acids 90-138 of Human GBDR1.
