84-2338-18　［取扱停止］GAS2L1 (GAS2-like Protein 1, GAS2-Related Protein on Chromosome 22, Growth arrest-specific Protein 2-like 1, GAS2L1, GAR22) 50ul　222874

特徴

• The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases.
• Gas2, a component of the microfilament system, is cleaved by a caspase (caspase-3 or caspase-7) at Asparagine 278 during apoptosis.
• The cleaved form of Gas2 dramatically induces the re-arrangement of the Actin cytoskeleton and causes potent changes in the shape of the affected cells.
• Gas2 is a cytoskeleton and peripheral membrane protein that colocalizes with Actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts.
• Gas2 is mainly membrane-associated, but when hyperphosphorylated it will accumulate at membrane ruffles, indicating Gas2 involvement in that process.
• Gar22 (Gas2-related protein on chromosome 22), also designated growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one CH (calponinhomo-logy) domain.
• It is thought to be involved in the cross-linking of microtubules and microfilaments.
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.