GALT (galactose-1-phosphate uridylyltransferase) is a 379 amino acid member of the galactose-1-phosphate uridylyltransferase type 1 family of proteins.
GALT exists as a homodimer and is believed to play a role in galactose metabolism.
More specifically, GALT is responsible for catalyzing the reaction of UDP-glucose with alpha-D-galactose 1-phosphate to produce alpha-D-glucose 1-phosphate and UDP-galactose.
This is the second step of the Leloir pathway of galactose metabolism.
The products of this reaction will either enter the glycolytic pathway to yield energy (alpha-D-glucose 1-phosphate) or be used as a galactosyl donor in the synthesis of glycoproteins and glycolipids (UDP-galactose).
Mutations in the gene encoding GALT can lead to galactosemia, a disorder (occurring from the inability to metabolize galactose) that is characterized by cataracts, mental retardation and jaundice.
In newborns, galactosemia can be fatal if lactose is not removed from the diet.
Applications:Suitable for use in Western Blot, Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid PBS, 0.1% sodium azide, 50% glycerol.
Specificity：Recognizes endogenous levels of GALT. Species Crossreactivity: Human, mouse, rat
